香港及澳門，[2024年7月18日] — 今天，輝瑞宣佈於香港推出二價 RSVpreF 疫苗，用於針對 60 歲或以上長者因 RSV 病毒引起的下呼吸道疾病（LRTD），以及初生至六個月大嬰兒（於孕婦懷孕期間接種*）因 RSV 病毒引起的 LRTD 和嚴重 LRTD。1 輝瑞是目前唯一一間公司提供同時適用於長者及孕婦的 RSV 疫苗。
RSV 是一種傳染性病毒，是引致全球各地呼吸系統疾病的常見起因。3,4 該病毒會損害肺部和呼吸道，可能導致嬰兒（尤其是早產或 6 個月以下嬰兒）以及高風險長者群組出現嚴重併發症或死亡。4-6 於2019年，全球已錄得 3,300 萬宗與 RSV 相關的急性下呼吸道感染，其中 101,400 宗死亡個案涉及 5 歲或以下兒童。7 至於 65 歲或以上長者，在 2015 年，全球疾病負擔數字估計為 33.6 萬人入院、14,100 人在住院期間死亡。8 在香港，RSV 病毒是導致一歲以下幼童住院的頭號呼吸道病毒（佔超過一半案例），9 亦是住院長者死亡的常見原因。10
輝瑞香港及澳門區域總經理Krishnamoorthy Sundaresan 表示：「這款二價 RSVpreF 疫苗在市場推出，再一次表明我們回應公共衛生需要的決心。透過此疫苗，我們可為免疫力較弱的群組 – 嬰兒和長者 – 提供針對 RSV 病毒的保護。」11
RSV 疾病主要由 RSV A 及 RSV B 兩種病毒亞群引起，兩種病毒可共同流行或隨著每個週期交替主導。12 這款二價疫苗不含佐劑，並由兩種融合前 F 蛋白組成，以發揮針對 RSV A 和 B 病毒種類的理想效果，並已證明為安全有效。11
輝瑞香港及澳門醫學總監Eugenia Ng 表示：「此疫苗亦配合香港衛生署的基層醫療健康藍圖，推動預防勝於治療的概念，以改善市民健康。現在除了長者之外，初生至六個月大嬰兒亦可得到保護，幫助他們抵抗嚴重 RSV 疾病，而 RSV 疾病在這些嬰兒中導致的疾病負擔最高。」在香港，每年每 1 萬名 6 個月或以下嬰兒中，就有 233.4 至 311.2 名因感染 RSV 病毒而需要入院接受治療。13
如欲了解更多最新二價RSV疫苗的相關資訊，請向所屬地區的醫護人員查詢。
* 有關建議的懷孕週期接種時間表，請參閱所屬地區的處方信息。
About RSVpreF Vaccine
Pfizer currently is the only company with an RSV vaccine to help protect older adults, as well as infants through maternal immunization. This bivalent vaccine was designed to provide broad protection against all RSV-LRTD, regardless of the virus subgroup. The RSV fusion protein (F) in the prefusion conformation is a major target of virus infection blocking antibodies and is the basis of Pfizer’s RSV vaccine. Sequence variability in F between RSV subgroup A and B strains clusters in potent neutralizing antibody binding sites on prefusion F.
About Pfizer: Breakthroughs That Change Patients’ Lives
At Pfizer, we apply science and our global resources to bring therapies to people that extend and significantly improve their lives. We strive to set the standard for quality, safety and value in the discovery, development and manufacture of health care products, including innovative medicines and vaccines. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. Consistent with our responsibility as one of the world's premier innovative biopharmaceutical companies, we collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world. For 175 years, we have worked to make a difference for all who rely on us. We routinely post information that may be important to investors on our website at www.Pfizer.com.hk. In addition, to learn more, please visit us on www.Pfizer.com.hk.
References:
1. Respiratory syncytial virus vaccine Prescribing Information. Pfizer Corporation Hong Kong Limited: Version MAR 2024.
2. Respiratory syncytial virus vaccine (bivalent, recombinant) Package Leaflet. Pfizer Europe. Version: 08/2023.
3. World Health Organization. Respiratory Syncytial Virus (RSV) disease. Available at: www.who.int/teams/health-product-policy-and-standards/standards-and-specifications/vaccine-standardization/respiratory-syncytial-virus-disease. Accessed May 2024.
4. Centers for Disease Control and Prevention. RSV transmission. Available at: www.cdc.gov/rsv/about/transmission.html. Accessed May 2024.
5. Centers for Disease Control and Prevention. Respiratory syncytial virus infection (RSV) – Older adults are at high risk for severe RSV infection fact sheet. Available at: www.cdc.gov/rsv/factsheet-older-adults.pdf. Accessed May 2024.
6. Centers for Disease Control and Prevention. RSV in Infants and Young Children. Available at: www.cdc.gov/rsv/high-risk/infants-young-children.html. Accessed May 2024.
7. Li Y, Wang X, Blau DM, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Lancet 2022;399:2047-2064.
8. Shi T, Denouel A, Tietjen AK, et al. Global disease burden estimates of respiratory syncytial virus-associated acute respiratory infection in older adults in 2015: A systematic review and meta-analysis. J Infect Dis 2020;222:S577-S583.
9. Chan PKS, Tam WWS, Lee TC, et al. Hospitalization incidence, mortality and seasonality of common respiratory viruses over a period of 15 years in a developed subtropical city. Medicine (Baltimore) 2015;94:e2024.
10. Wang Y, Fekadu G, You JHS. Comparative Cost-Effectiveness Analysis of Respiratory Syncytial Virus Vaccines for Older Adults in Hong Kong. Vaccines 2023;11(10):1605. https://doi.org/10.3390/vaccines11101605
11. Awosika AO, Patel P. Respiratory Syncytial Virus Prefusion F (RSVPreF3) Vaccine. [Updated 2024 Mar 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK594261/
12. Ciarlitto, C., Vittucci, A.C., Antilici, L. et al. Respiratory Syncityal Virus A and B: three bronchiolitis seasons in a third level hospital in Italy. Ital J Pediatr 2019;45(115). https://doi.org/10.1186/s13052-019-0704-0
13. Chiu SS, Chan KH, Chen H, et al. Virologically Confirmed Population-based Burden of Hospitalization Caused by Respiratory Syncytial Virus, Adenovirus, and Parainfluenza Viruses in Children in Hong Kong. Pediatr Infect Dis J 2010;29(12):1088-1092.
PP-A1G-HKG-0058 JUL 2024